Version 5.4
Mus musculus Protein: Parl
Summary
InnateDB Protein IDBP-143738.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Parl
Protein Name presenilin associated, rhomboid-like
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000045361
InnateDB Gene IDBG-143736 (Parl)
Protein Structure
UniProt Annotation
Function Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion inner membrane {ECO:0000269PubMed:16839884}; Multi-pass membrane protein {ECO:0000269PubMed:16839884}.P-beta: Nucleus. Note=Translocated into the nucleus by an unknown mechanism.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1277152
InterPro IPR022764 Peptidase S54, rhomboid domain
PFAM PF01694
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5XJY4
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 381038
UniGene Mm.448399
RefSeq NP_001005767
MGI ID
MGI Symbol Parl
OMIM
CCDS CCDS28044
HPRD
IMGT
EMBL AK151652 BC083153
GenPept AAH83153 BAE30581

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca