Version 5.4
Mus musculus Gene: Parl
Summary
InnateDB Gene IDBG-143736.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Parl
Gene Name presenilin associated, rhomboid-like
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000033918
Encoded Proteins
IDBP-143738
presenilin associated, rhomboid-like
IDBP-538273
presenilin associated, rhomboid-like
IDBP-539903
presenilin associated, rhomboid-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175193:
This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:20279820-20302387
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000048642 ENSMUSP00000045361
ENSMUST00000136252 ENSMUSP00000119470
ENSMUST00000155832
ENSMUST00000123070
ENSMUST00000126001
ENSMUST00000136700
ENSMUST00000133153 ENSMUSP00000119060
ENSMUST00000143648
ENSMUST00000152887
ENSMUST00000153275
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000175193
View Gene Order
ENSBTAG00000014460
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.371737 Mm.448399
RefSeq NM_001005767
OMIM
CCDS CCDS28044
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca