InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ap1b1

Summary

InnateDB Protein

IDBP-143795.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ap1b1

Protein Name

adaptor protein complex AP-1, beta 1 subunit

Synonyms

Adtb1; b2b1660Clo;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000009234

InnateDB Gene

IDBG-143791 (Ap1b1)

Protein Structure

UniProt Annotation

Function

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

Subcellular Localization

Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0008565	protein transporter activity

Biological Process

GO:0006886	intracellular protein transport
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport

Cellular Component

GO:0005802	trans-Golgi network
GO:0030117	membrane coat
GO:0030131	clathrin adaptor complex
GO:0030665	clathrin-coated vesicle membrane

Protein Structure and Domains

PDB ID

MGI:1096368

InterPro

IPR000225 Armadillo
IPR000357 HEAT
IPR002553 Clathrin/coatomer adaptor, adaptin-like, N-terminal
IPR008152 Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
IPR009028 Coatomer/calthrin adaptor appendage, C-terminal subdomain
IPR013041 Coatomer/clathrin adaptor appendage, Ig-like subdomain
IPR015151 Beta-adaptin appendage, C-terminal subdomain
IPR016024 Armadillo-type fold
IPR016342 AP-1, 2,4 complex subunit beta

PFAM

PF00514
PF02985
PF01602
PF02883
PF09066

PRINTS

PIRSF

PIRSF002291

SMART

SM00185
SM00809
SM01020

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt