InnateDB Protein
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IDBP-143866.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Eif3j2
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Protein Name
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predicted gene 9781
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000054421
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InnateDB Gene
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IDBG-143864 (Eif3j2)
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Protein Structure
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Function |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA. {ECO:0000255HAMAP-Rule:MF_03009}.
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Subcellular Localization |
Cytoplasm {ECO:0000255HAMAP-Rule:MF_03009}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
26 [view]
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Molecular Function |
Accession |
GO Term |
GO:0003743
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translation initiation factor activity
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Biological Process |
GO:0001731
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formation of translation preinitiation complex
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GO:0006446
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regulation of translational initiation
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Cellular Component |
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PDB ID |
MGI:3704486
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InterPro |
IPR013906
Eukaryotic translation initiation factor 3 subunit J
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PFAM |
PF08597
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q66JS6
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PhosphoSite |
PhosphoSite-Q66JS6
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TrEMBL |
Q66JW9
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UniProt Splice Variant |
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Entrez Gene |
100042807
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UniGene |
Mm.489777
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RefSeq |
NP_001242984
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MGI ID |
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MGI Symbol |
Eif3j2
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OMIM |
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CCDS |
CCDS57122
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HPRD |
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IMGT |
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EMBL |
AK082048
BC080724
BC080788
BC108355
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GenPept |
AAH80724
AAH80788
AAI08356
BAC38399
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