InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CIITA

Summary

InnateDB Protein

IDBP-14389.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CIITA

Protein Name

class II, major histocompatibility complex, transactivator

Synonyms

C2TA; CIITAIV; MHC2TA; NLRA;

Species

Homo sapiens

Ensembl Protein

ENSP00000371257

InnateDB Gene

IDBG-14377 (CIITA)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	69 [view]
Protein-Protein	28 [view]
Protein-DNA	41 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0008022	protein C-terminus binding
GO:0016301	kinase activity
GO:0016746	transferase activity, transferring acyl groups
GO:0032403	protein complex binding
GO:0033613	activating transcription factor binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006955	immune response
GO:0016310	phosphorylation
GO:0019221	cytokine-mediated signaling pathway
GO:0032966	negative regulation of collagen biosynthetic process
GO:0034341	response to interferon-gamma
GO:0045345	positive regulation of MHC class I biosynthetic process
GO:0045348	positive regulation of MHC class II biosynthetic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046677	response to antibiotic
GO:0060333	interferon-gamma-mediated signaling pathway