InnateDB Protein
|
IDBP-143913.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Slc27a5
|
Protein Name
|
solute carrier family 27 (fatty acid transporter), member 5
|
Synonyms
|
FACVL3; FATP5; Vlacsr; VLCS-H2; VLCSH2;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000032539
|
InnateDB Gene
|
IDBG-143911 (Slc27a5)
|
Protein Structure
|
|
Function |
Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
In liver expressed in a periportal distribution. {ECO:0000269PubMed:11980911}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
|
Protein-Protein |
2
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:1347100
|
InterPro |
IPR000873
AMP-dependent synthetase/ligase
|
PFAM |
PF00501
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q4LDG0
|
PhosphoSite |
PhosphoSite-Q4LDG0
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
26459
|
UniGene |
Mm.10984
|
RefSeq |
NP_033538
|
MGI ID |
|
MGI Symbol |
Slc27a5
|
OMIM |
|
CCDS |
CCDS20821
|
HPRD |
|
IMGT |
|
EMBL |
AF072760
AJ223959
BC013272
BC013335
BC145823
BC145825
|
GenPept |
AAC40189
AAH13272
AAH13335
AAI45824
AAI45826
CAA11688
|
|
|