InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tubb2b

Summary

InnateDB Protein

IDBP-143970.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tubb2b

Protein Name

tubulin, beta 2B

Synonyms

2410129E14Rik; brdp;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000075178

InnateDB Gene

IDBG-143968 (Tubb2b)

Protein Structure

UniProt Annotation

Function

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). TUBB2B is implicated in neuronal migration (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}.

Disease Associations

Tissue Specificity

Strong expression is detected in the developing cortex and peripheral nervous system, as well as in the adult cerebellum, hippocampus and olfactory bulb. {ECO:0000269PubMed:19465910}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0001764	neuron migration
GO:0006184	GTP catabolic process
GO:0007017	microtubule-based process
GO:0051258	protein polymerization

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005874	microtubule
GO:0005886	plasma membrane
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

MGI:1920960

InterPro

IPR000217 Tubulin
IPR002452 Alpha tubulin
IPR002453 Beta tubulin
IPR002454 Gamma tubulin
IPR002967 Delta tubulin
IPR003008 Tubulin/FtsZ, GTPase domain
IPR004057 Epsilon tubulin
IPR008280 Tubulin/FtsZ, C-terminal
IPR018316 Tubulin/FtsZ, 2-layer sandwich domain
IPR019605 Misato Segment II tubulin-like domain

PFAM

PF00091
PF03953
PF10644

PRINTS

PR01161
PR01162
PR01163
PR01164
PR01224
PR01519

PIRSF

SMART

SM00864
SM00865

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt