Version 5.4
Mus musculus Gene: Tubb2b
Summary
InnateDB Gene IDBG-143968.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tubb2b
Gene Name tubulin, beta 2B class IIB
Synonyms 2410129E14Rik; brdp
Species Mus musculus
Ensembl Gene ENSMUSG00000045136
Encoded Proteins
IDBP-143970
tubulin, beta 2B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137285:
The protein encoded by this gene is a beta isoform of tubulin, which binds GTP and is a major component of microtubules. This gene is highly similar to TUBB2A and TUBB2C. Defects in this gene are a cause of asymmetric polymicrogyria. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:34127008-34130354
Strand Reverse strand
Band A3.3
Transcripts
ENSMUST00000075774 ENSMUSP00000075178
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 33 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0001764 neuron migration
GO:0006184 GTP catabolic process
GO:0007017 microtubule-based process
GO:0051258 protein polymerization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000137285
View Gene Order
Pathways
NETPATH
REACTOME
REACT_245720
Recruitment of mitotic centrosome proteins and complexes pathway
REACT_224389
Gap junction trafficking and regulation pathway
REACT_240530
G2/M Transition pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_224553
Hemostasis pathway
REACT_207679
Separation of Sister Chromatids pathway
REACT_257923
Recycling pathway of L1 pathway
REACT_227366
Gap junction assembly pathway
REACT_269412
Hedgehog 'off' state pathway
REACT_198961
Resolution of Sister Chromatid Cohesion pathway
REACT_209837
Membrane Trafficking pathway
REACT_268398
Orphan transporters pathway
REACT_258900
Chaperonin-mediated protein folding pathway
REACT_188804
Cell Cycle pathway
REACT_230745
Immune System pathway
REACT_241408
M Phase pathway
REACT_247926
Metabolism of proteins pathway
REACT_246290
Recruitment of NuMA to mitotic centrosomes pathway
REACT_247933
Post-chaperonin tubulin folding pathway pathway
REACT_218773
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane pathway
REACT_199117
Kinesins pathway
REACT_198649
Factors involved in megakaryocyte development and platelet production pathway
REACT_246508
Mitotic G2-G2/M phases pathway
REACT_196550
MHC class II antigen presentation pathway
REACT_260833
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
REACT_245534
Protein folding pathway
REACT_199403
Mitotic Metaphase and Anaphase pathway
REACT_256756
Mitotic Prometaphase pathway
REACT_261444
Axon guidance pathway
REACT_208406
Transport of connexons to the plasma membrane pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_219680
L1CAM interactions pathway
REACT_229531
Adaptive Immune System pathway
REACT_188576
Developmental Biology pathway
REACT_250064
Signaling by Hedgehog pathway
REACT_217189
Gap junction trafficking pathway
REACT_188257
Signal Transduction pathway
REACT_258053
Formation of tubulin folding intermediates by CCT/TriC pathway
REACT_202512
Mitotic Anaphase pathway
REACT_199054
Translocation of GLUT4 to the plasma membrane pathway
REACT_245663
Prefoldin mediated transfer of substrate to CCT/TriC pathway
REACT_253753
Centrosome maturation pathway
KEGG
mmu04540
Gap junction pathway
mmu04145
Phagosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_150425
Resolution of Sister Chromatid Cohesion pathway
REACT_682
Mitotic Prometaphase pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_15510
Recruitment of NuMA to mitotic centrosomes pathway
REACT_15296
Recruitment of mitotic centrosome proteins and complexes pathway
REACT_121399
MHC class II antigen presentation pathway
REACT_25201
Kinesins pathway
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_16967
Post-chaperonin tubulin folding pathway pathway
REACT_16936
Prefoldin mediated transfer of substrate to CCT/TriC pathway
REACT_16956
Formation of tubulin folding intermediates by CCT/TriC pathway
REACT_11039
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane pathway
REACT_11050
Transport of connexons to the plasma membrane pathway
REACT_9509
Gap junction assembly pathway
REACT_147867
Translocation of GLUT4 to the plasma membrane pathway
REACT_22365
Recycling pathway of L1 pathway
REACT_22205
L1CAM interactions pathway
REACT_16952
Protein folding pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_111045
Developmental Biology pathway
REACT_228134
Signaling by Hedgehog pathway
REACT_18266
Axon guidance pathway
REACT_111102
Signal Transduction pathway
REACT_267634
Hedgehog 'off' state pathway
REACT_9411
Gap junction trafficking pathway
REACT_17004
Chaperonin-mediated protein folding pathway
REACT_115566
Cell Cycle pathway
REACT_267716
Orphan transporters pathway
REACT_17015
Metabolism of proteins pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_17029
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
REACT_910
M Phase pathway
REACT_1275
Mitotic Anaphase pathway
REACT_15479
Centrosome maturation pathway
REACT_2203
G2/M Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_21391
Mitotic G2-G2/M phases pathway
REACT_9480
Gap junction trafficking and regulation pathway
REACT_604
Hemostasis pathway
REACT_11123
Membrane Trafficking pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
KEGG
hsa05130
Pathogenic Escherichia coli infection pathway
hsa04540
Gap junction pathway
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt Q9CWF2
TrEMBL B2RSN3 Q8BK89
UniProt Splice Variant
Entrez Gene 73710
UniGene Mm.379227
RefSeq NM_023716
OMIM
CCDS CCDS26445
HPRD
IMGT
MGI ID MGI:1920960
MGI Symbol Tubb2b
EMBL AK010786 AK075618 AK168908 BC138935 BC138936 CH466546
GenPept AAI38936 AAI38937 BAB27182 BAC35862 BAE40722 EDL40886
RNA Seq Atlas 73710

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca