InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Noxa1

Summary

InnateDB Protein

IDBP-144014.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Noxa1

Protein Name

NADPH oxidase activator 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000037423

InnateDB Gene

IDBG-144012 (Noxa1)

Protein Structure

UniProt Annotation

Function

Functions as an activator of NOX1, a superoxide- producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3. {ECO:0000269PubMed:12473664, ECO:0000269PubMed:15326186, ECO:0000269PubMed:16814099}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:16814099}. Cell membrane {ECO:0000269PubMed:16814099}. Note=Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1.

Disease Associations

Tissue Specificity

Widely expressed with a tissue distribution similar to the one of NOX1. Detected in colon, uterus, prostate, small intestine, stomach, lung, thyroid, aorta, inner ear and salivary glands. Expressed in colon, small intestine and aortic smooth muscle cells (at protein level). {ECO:0000269PubMed:12473664, ECO:0000269PubMed:12657628, ECO:0000269PubMed:15949904, ECO:0000269PubMed:16814099}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016176	superoxide-generating NADPH oxidase activator activity
GO:0017124	SH3 domain binding
GO:0019899	enzyme binding
GO:0048365	Rac GTPase binding

Biological Process

GO:0006801	superoxide metabolic process
GO:0010310	regulation of hydrogen peroxide metabolic process
GO:0043085	positive regulation of catalytic activity
GO:0060263	regulation of respiratory burst

Cellular Component

GO:0005737	cytoplasm
GO:0043020	NADPH oxidase complex

Protein Structure and Domains

PDB ID

MGI:2449980

InterPro

IPR000270 Phox/Bem1p
IPR001452 SH3 domain
IPR011511 Variant SH3 domain
IPR013026 Tetratricopeptide repeat-containing domain
IPR019734 Tetratricopeptide repeat

PFAM