Version 5.4
Mus musculus Gene: Noxa1
Summary
InnateDB Gene IDBG-144012.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Noxa1
Gene Name NADPH oxidase activator 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000036805
Encoded Proteins
IDBP-144014
NADPH oxidase activator 1
IDBP-251901
NADPH oxidase activator 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 20110267
[Homo sapiens] NOXA1 together with NADPH oxidase organizer 1 (NOXO1) are key regulatory subunits of the NADPH oxidase NOX1, the activity of which is regulated through MAP kinase (MAPK), protein kinase C (PKC), and protein kinase A (PKA)-dependent phosphorylation on Ser-282 and Ser-172 of NOXA1.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000188747:
This gene encodes a protein which activates NADPH oxidases, enzymes which catalyze a reaction generating reactive oxygen species. The encoded protein contains four N-terminal tetratricopeptide domains and a C-terminal Src homology 3 domain. Interaction between the encoded protein and proteins in the oxidase regulatory complex occur via the tetratricopeptide domains. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:25085667-25095149
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000044018 ENSMUSP00000037423
ENSMUST00000114373 ENSMUSP00000110014
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016176 superoxide-generating NADPH oxidase activator activity
GO:0017124 SH3 domain binding
GO:0019899 enzyme binding
GO:0048365 Rac GTPase binding
Biological Process
GO:0006801 superoxide metabolic process
GO:0010310 regulation of hydrogen peroxide metabolic process
GO:0043085 positive regulation of catalytic activity
GO:0060263 regulation of respiratory burst
Cellular Component
GO:0005737 cytoplasm
GO:0043020 NADPH oxidase complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000188747
View Gene Order
ENSBTAG00000012121
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
rac1_pathway
RAC1 signaling pathway
Cross-References
SwissProt Q8CJ00
TrEMBL
UniProt Splice Variant
Entrez Gene 241275
UniGene Mm.218774
RefSeq NM_172204 NM_001163626
OMIM
CCDS CCDS15749 CCDS50524
HPRD
IMGT
MGI ID MGI:2449980
MGI Symbol Noxa1
EMBL AF539798 AK087263 AL732585 AY255770 BC047532
GenPept AAH47532 AAN75143 AAP13481 BAC39832 CAM17999 CAM18000
RNA Seq Atlas 241275

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca