InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: En2

Summary

InnateDB Protein

IDBP-144064.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

En2

Protein Name

engrailed 2

Synonyms

BB131122; En-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000036761

InnateDB Gene

IDBG-144062 (En2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Cerebellar granule cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0030182	neuron differentiation
GO:0030901	midbrain development
GO:0030902	hindbrain development
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048666	neuron development

Cellular Component

GO:0005634	nucleus
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:95390

InterPro

IPR000747 Homeodomain engrailed
IPR001356 Homeobox domain
IPR009057 Homeodomain-like
IPR019549 Homeobox engrailed, C-terminal
IPR020479 Homeodomain, metazoa

PFAM

PF00046
PF10525

PRINTS

PR00026
PR00024

PIRSF

SMART

SM00389

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt