InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Shb

Summary

InnateDB Protein

IDBP-144248.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Shb

Protein Name

src homology 2 domain-containing transforming protein B

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000060433

InnateDB Gene

IDBG-144246 (Shb)

Protein Structure

UniProt Annotation

Function

Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic- FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Associates with membrane lipid rafts upon TCR stimulation. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in heart, liver, brain and kidney (at protein level). {ECO:0000269PubMed:8302579}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0005070	SH3/SH2 adaptor activity
GO:0005515	protein binding

Biological Process

GO:0001525	angiogenesis
GO:0001568	blood vessel development
GO:0006469	negative regulation of protein kinase activity
GO:0006915	apoptotic process
GO:0009967	positive regulation of signal transduction
GO:0030097	hemopoiesis
GO:0030154	cell differentiation
GO:0042100	B cell proliferation
GO:0045931	positive regulation of mitotic cell cycle
GO:0048514	blood vessel morphogenesis
GO:0071425	hematopoietic stem cell proliferation
GO:1900194	negative regulation of oocyte maturation