InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bmper

Summary

InnateDB Protein

IDBP-144264.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bmper

Protein Name

BMP-binding endothelial regulator

Synonyms

3110056H04Rik; Crim3; CV-2; Cv2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000071872

InnateDB Gene

IDBG-144262 (Bmper)

Protein Structure

UniProt Annotation

Function

Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes. {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000269PubMed:14516682}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001657	ureteric bud development
GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:0010594	regulation of endothelial cell migration
GO:0030514	negative regulation of BMP signaling pathway
GO:0042118	endothelial cell activation
GO:0048839	inner ear development
GO:0060393	regulation of pathway-restricted SMAD protein phosphorylation
GO:0070374	positive regulation of ERK1 and ERK2 cascade

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space

Protein Structure and Domains

PDB ID

MGI:1920480

InterPro

IPR001007 von Willebrand factor, type C
IPR001846 von Willebrand factor, type D domain
IPR002919 Trypsin Inhibitor-like, cysteine rich domain
IPR014853 Uncharacterised domain, cysteine-rich

PFAM

PF00093
PF00094
PF01826
PF08742

PRINTS

PIRSF

SMART

SM00214
SM00216
SM00832

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8CJ69