Version 5.4
Mus musculus Gene: Bmper
Summary
InnateDB Gene IDBG-144262.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Bmper
Gene Name BMP-binding endothelial regulator
Synonyms 3110056H04Rik; Crim3; CV-2; Cv2
Species Mus musculus
Ensembl Gene ENSMUSG00000031963
Encoded Proteins
IDBP-144264
BMP-binding endothelial regulator
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a secreted protein that contains five Von Willebrand factor type C domains and a Von Willebrand factor type D domain and a trypsin inhibitory-like domain. The encoded protein binds to bone morphogenetic proteins (BMP) and regulates their activity. Mutation of the related gene in humans causes diaphanospondylodysostosis. [provided by RefSeq, Mar 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:23223076-23485202
Strand Forward strand
Band A3
Transcripts
ENSMUST00000071982 ENSMUSP00000071872
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001657 ureteric bud development
GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:0010594 regulation of endothelial cell migration
GO:0030514 negative regulation of BMP signaling pathway
GO:0042118 endothelial cell activation
GO:0048839 inner ear development
GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000164619
View Gene Order
ENSBTAG00000010866
Not yet available
Cross-References
SwissProt Q8CJ69
TrEMBL
UniProt Splice Variant
Entrez Gene 73230
UniGene Mm.335020 Mm.407956
RefSeq NM_028472
OMIM
CCDS CCDS22929
HPRD
IMGT
MGI ID MGI:1920480
MGI Symbol Bmper
EMBL AF454954 AK014221 AY263358 BC042718 BC066153
GenPept AAH42718 AAH66153 AAN45857 AAP88382 BAB29213
RNA Seq Atlas 73230

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca