InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Srrm2

Summary

InnateDB Protein

IDBP-144295.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Srrm2

Protein Name

serine/arginine repetitive matrix 2

Synonyms

5033413A03Rik; AA410130; mKIAA0324; SRm300;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000085993

InnateDB Gene

IDBG-144289 (Srrm2)

Protein Structure

UniProt Annotation

Function

Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate. Binds to RNA (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus speckle {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 173 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	173 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0044822	poly(A) RNA binding
GO:0047485	protein N-terminus binding
GO:0070742	C2H2 zinc finger domain binding

Biological Process

GO:0006397	mRNA processing
GO:0008150	biological_process
GO:0008380	RNA splicing

Cellular Component

GO:0005634	nucleus
GO:0015030	Cajal body
GO:0016607	nuclear speck
GO:0071013	catalytic step 2 spliceosome

Protein Structure and Domains

PDB ID

MGI:1923206

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BTI8

PhosphoSite

PhosphoSite-Q8BTI8

TrEMBL

UniProt Splice Variant

Entrez Gene

75956

UniGene

Mm.5222

RefSeq

NP_780438

MGI ID

MGI Symbol

Srrm2

OMIM

CCDS

CCDS37475

HPRD

IMGT

EMBL

AC122821 AK090123 AK122248 AK171001 BC027781 BC092355

GenPept

AAH27781 AAH92355 BAC41104 BAC65530 BAE42172