InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ABR

Summary

InnateDB Protein

IDBP-14434.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ABR

Protein Name

active BCR-related gene

Synonyms

MDB;

Species

Homo sapiens

Ensembl Protein

ENSP00000303909

InnateDB Gene

IDBG-14430 (ABR)

Protein Structure

UniProt Annotation

Function

GTPase-activating protein for RAC and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them.

Subcellular Localization

Disease Associations

Tissue Specificity

Highly enriched in the brain. Much weaker expression in heart, lung and muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0030675	Rac GTPase activator activity

Biological Process

GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007420	brain development
GO:0030036	actin cytoskeleton organization
GO:0030336	negative regulation of cell migration
GO:0032496	response to lipopolysaccharide
GO:0032855	positive regulation of Rac GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0042472	inner ear morphogenesis
GO:0043065	positive regulation of apoptotic process
GO:0043314	negative regulation of neutrophil degranulation
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0050728	negative regulation of inflammatory response
GO:0050766	positive regulation of phagocytosis
GO:0050885	neuromuscular process controlling balance
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0005622	intracellular
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000008 C2 domain
IPR000198 Rho GTPase-activating protein domain
IPR000219 Dbl homology (DH) domain
IPR001849 Pleckstrin homology domain
IPR008936 Rho GTPase activation protein

PFAM

PF00168
PF00620
PF00621
PF00169

PRINTS

PR00360

PIRSF

SMART

SM00239
SM00324
SM00325
SM00233

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt