Version 5.4
Homo sapiens Gene: ABR
Summary
InnateDB Gene IDBG-14430.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ABR
Gene Name active BCR-related
Synonyms MDB
Species Homo sapiens
Ensembl Gene ENSG00000159842
Encoded Proteins
IDBP-14434
active BCR-related gene
IDBP-14436
active BCR-related gene
IDBP-598022
active BCR-related gene
IDBP-602730
active BCR-related gene
IDBP-588344
active BCR-related gene
IDBP-763750
IDBP-758936
IDBP-762099
IDBP-761456
IDBP-760897
IDBP-760018
IDBP-759365
IDBP-764452
IDBP-764586
IDBP-763754
IDBP-760121
IDBP-758794
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is similar to the protein encoded by the breakpoint cluster region gene located on chromosome 22. The protein encoded by this gene contains a GTPase-activating protein domain, a domain found in members of the Rho family of GTP-binding proteins. Functional studies in mice determined that this protein plays a role in vestibular morphogenesis. Alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:1003518-1229021
Strand Reverse strand
Band p13.3
Transcripts
ENST00000302538 ENSP00000303909
ENST00000291107 ENSP00000291107
ENST00000544583 ENSP00000442048
ENST00000536794 ENSP00000437429
ENST00000543210 ENSP00000445198
ENST00000574437 ENSP00000461565
ENST00000573559 ENSP00000460937
ENST00000574257
ENST00000573667
ENST00000571543
ENST00000576964
ENST00000570688
ENST00000571383
ENST00000574875
ENST00000570441 ENSP00000459820
ENST00000571120
ENST00000577052
ENST00000576668
ENST00000572650
ENST00000572441 ENSP00000459553
ENST00000572152 ENSP00000460248
ENST00000574139 ENSP00000461629
ENST00000573895
ENST00000571945 ENSP00000459118
ENST00000570525 ENSP00000459761
ENST00000574048
ENST00000575934 ENSP00000460770
ENST00000574632
ENST00000572585
ENST00000573325
ENST00000575770
ENST00000571797 ENSP00000461795
ENST00000574544 ENSP00000458294
ENST00000571306
ENST00000574266 ENSP00000459406
ENST00000571022
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0030675 Rac GTPase activator activity
Biological Process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0007420 brain development
GO:0030036 actin cytoskeleton organization
GO:0030336 negative regulation of cell migration
GO:0032321 positive regulation of Rho GTPase activity
GO:0032496 response to lipopolysaccharide
GO:0032855 positive regulation of Rac GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0042472 inner ear morphogenesis
GO:0043065 positive regulation of apoptotic process
GO:0043314 negative regulation of neutrophil degranulation
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0050728 negative regulation of inflammatory response
GO:0050766 positive regulation of phagocytosis
GO:0050885 neuromuscular process controlling balance
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000017631
View Gene Order
ENSBTAG00000008424
Not yet available
Pathways
NETPATH
REACTOME
REACT_13638
NRAGE signals death through JNK pathway
REACT_18407
G alpha (12/13) signalling events pathway
REACT_11051
Rho GTPase cycle pathway
REACT_11061
Signalling by NGF pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_14797
Signaling by GPCR pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_13720
Cell death signalling via NRAGE, NRIF and NADE pathway
KEGG
INOH
PID NCI
rac1_reg_pathway
Regulation of RAC1 activity
rhoa_reg_pathway
Regulation of RhoA activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.159306 Hs.742468
RefSeq NM_001092 NM_001159746 NM_001256847 NM_001282149 NM_021962 XM_006721507
HUGO
OMIM
CCDS CCDS10999 CCDS11000 CCDS54060 CCDS58497 CCDS73936
HPRD 02649
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca