InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bag4

Summary

InnateDB Protein

IDBP-144402.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bag4

Protein Name

BCL2-associated athanogene 4

Synonyms

2410112I15Rik; SODD;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000044725

InnateDB Gene

IDBG-144400 (Bag4)

Protein Structure

UniProt Annotation

Function

Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Prevents constitutive TNFRSF1A signaling (By similarity). Negative regulator of PARK2 translocation to damaged mitochondria (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0051087	chaperone binding

Biological Process

GO:0006915	apoptotic process
GO:0010763	positive regulation of fibroblast migration
GO:0030838	positive regulation of actin filament polymerization
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0042981	regulation of apoptotic process
GO:0045785	positive regulation of cell adhesion
GO:0051291	protein heterooligomerization
GO:0051496	positive regulation of stress fiber assembly
GO:0051897	positive regulation of protein kinase B signaling
GO:0071356	cellular response to tumor necrosis factor
GO:0071364	cellular response to epidermal growth factor stimulus
GO:0072659	protein localization to plasma membrane
GO:0090367	negative regulation of mRNA modification
GO:0097178	ruffle assembly
GO:2001145	negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity