InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dcp2

Summary

InnateDB Protein

IDBP-144526.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dcp2

Protein Name

DCP2 decapping enzyme homolog (S. cerevisiae)

Synonyms

2410015D23Rik; 5730537H01Rik; AL118268;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025350

InnateDB Gene

IDBG-144524 (Dcp2)

Protein Structure

UniProt Annotation

Function

Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety. {ECO:0000269PubMed:21070968}.

Subcellular Localization

Cytoplasm, P-body {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic, in processing bodies (PB). A minor amount is nuclear (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Strongly expressed in brain and testis. Weakly expressed in lung. Not detected in heart, liver, kidney and muscle (at protein level). {ECO:0000269PubMed:21070968}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0030145	manganese ion binding
GO:0050072	m7G(5')pppN diphosphatase activity