Version 5.4
Mus musculus Protein: Aldh1b1
Summary
InnateDB Protein IDBP-144538.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Aldh1b1
Protein Name aldehyde dehydrogenase 1 family, member B1
Synonyms 2700007F14Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000041260
InnateDB Gene IDBG-144536 (Aldh1b1)
Protein Structure
UniProt Annotation
Function ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion matrix {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004029 aldehyde dehydrogenase (NAD) activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006068 ethanol catabolic process
GO:0008152 metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID MGI:1919785
InterPro IPR015590 Aldehyde dehydrogenase domain
IPR016161 Aldehyde/histidinol dehydrogenase
PFAM PF00171
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CZS1
PhosphoSite PhosphoSite-Q9CZS1
TrEMBL G3UYH1
UniProt Splice Variant
Entrez Gene 72535
UniGene Mm.331583
RefSeq NP_082546
MGI ID
MGI Symbol Aldh1b1
OMIM
CCDS CCDS18139
HPRD
IMGT
EMBL AK012213 AK088396 AK150992 AK151349 AK151364 AK153416 AL772381 BC020001 BC086768
GenPept AAH20001 AAH86768 BAB28101 BAC40326 BAE30016 BAE30325 BAE30339 BAE31976

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca