InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GOLPH3

Summary

InnateDB Protein

IDBP-14461.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GOLPH3

Protein Name

golgi phosphoprotein 3 (coat-protein)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000265070

InnateDB Gene

IDBG-14459 (GOLPH3)

Protein Structure

UniProt Annotation

Function

Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis. {ECO:0000269PubMed:16263763, ECO:0000269PubMed:19553991, ECO:0000269PubMed:19837035, ECO:0000269PubMed:22745132, ECO:0000269PubMed:23027862, ECO:0000269PubMed:23345592, ECO:0000269PubMed:23500462}.

Subcellular Localization

Golgi apparatus, Golgi stack membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion intermembrane space. Cell membrane {ECO:0000250}. Endosome {ECO:0000250}. Note=Phosphatidylinositol 4-phosphate-binding and oligomerization participate in the recruitment onto Golgi membranes. {ECO:0000305}.

Disease Associations

Tissue Specificity

Detected in muscle fibers of patients with mitochondrial diseases; not detected in normal muscle fibers.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0070273	phosphatidylinositol-4-phosphate binding

Biological Process

GO:0007030	Golgi organization
GO:0008283	cell proliferation
GO:0009101	glycoprotein biosynthetic process
GO:0009306	protein secretion
GO:0010467	gene expression
GO:0010821	regulation of mitochondrion organization
GO:0016477	cell migration
GO:0030032	lamellipodium assembly
GO:0032008	positive regulation of TOR signaling
GO:0043001	Golgi to plasma membrane protein transport
GO:0045053	protein retention in Golgi apparatus
GO:0048194	Golgi vesicle budding
GO:0050714	positive regulation of protein secretion
GO:0050901	leukocyte tethering or rolling
GO:0060352	cell adhesion molecule production

Cellular Component

GO:0005739	mitochondrion
GO:0005758	mitochondrial intermembrane space
GO:0005768	endosome
GO:0005794	Golgi apparatus
GO:0005802	trans-Golgi network
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0031985	Golgi cisterna
GO:0032580	Golgi cisterna membrane