InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kremen1

Summary

InnateDB Protein

IDBP-144618.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kremen1

Protein Name

kringle containing transmembrane protein 1

Synonyms

AV002070; Kremen; Krm1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020662

InnateDB Gene

IDBG-144616 (Kremen1)

Protein Structure

UniProt Annotation

Function

Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

In the adult, widely expressed with high levels in heart, lung, kidney, skeletal muscle and testis. {ECO:0000269PubMed:11267660}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0006952	defense response
GO:0008150	biological_process
GO:0016055	Wnt signaling pathway

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1933988

InterPro

IPR000001 Kringle
IPR000859 CUB domain
IPR002889 Carbohydrate-binding WSC
IPR003614 Knottin, scorpion toxin-like
IPR013806 Kringle-like fold
IPR013994 Carbohydrate-binding WSC, subgroup
IPR017076 Kremen

PFAM

PF00051
PF00431
PF01822

PRINTS

PIRSF

PIRSF036961

SMART

SM00130
SM00042
SM00505
SM00321

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt