InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: YKT6

Summary

InnateDB Protein

IDBP-14466.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

YKT6

Protein Name

YKT6 v-SNARE homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000223369

InnateDB Gene

IDBG-14464 (YKT6)

Protein Structure

UniProt Annotation

Function

Vesicular soluble NSF attachment protein receptor (v- SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity. {ECO:0000269PubMed:15215310, ECO:0000269PubMed:9211930}.

Subcellular Localization

Cytoplasm, cytosol. Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Note=Probably cycles through vesicles between Golgi and endosomes.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005484	SNAP receptor activity
GO:0019706	protein-cysteine S-palmitoyltransferase activity

Biological Process

GO:0006810	transport
GO:0006888	ER to Golgi vesicle-mediated transport
GO:0006903	vesicle targeting
GO:0006904	vesicle docking involved in exocytosis
GO:0008152	metabolic process
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0042147	retrograde transport, endosome to Golgi

Cellular Component

GO:0000139	Golgi membrane
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005768	endosome
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0030659	cytoplasmic vesicle membrane
GO:0031201	SNARE complex
GO:0070062	extracellular vesicular exosome