InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tdrd7

Summary

InnateDB Protein

IDBP-144672.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tdrd7

Protein Name

tudor domain containing 7

Synonyms

5730495N10Rik; AI447470; PCTAIRE2BP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099993

InnateDB Gene

IDBG-144670 (Tdrd7)

Protein Structure

UniProt Annotation

Function

Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis. {ECO:0000269PubMed:21436445}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11527406, ECO:0000269PubMed:17141210, ECO:0000269PubMed:21436445}. Note=Localizes to cytoplasmic RNA granules. Present in chromatoid body (CB) of spermatids (mammalian counterpart of germplasm, pole plasm or polar granules in Drosophila germ cells), also named processing bodies (P-bodies) in somatic cells. Detected in the multilobular cytoplasmic CBs (also called intermitochondrial cementin) in pachytene spermatocytes and as a single perinuclear CB in haploid round spermatids.

Disease Associations

Tissue Specificity

Mainly expressed in testis. Expressed in spermatogonia, spermatocytes and round spermatids (at protein level). Also expressed in the developing lens. {ECO:0000269PubMed:17141210, ECO:0000269PubMed:21436445}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0002089	lens morphogenesis in camera-type eye
GO:0007281	germ cell development
GO:0007283	spermatogenesis
GO:0010608	posttranscriptional regulation of gene expression
GO:0070306	lens fiber cell differentiation

Cellular Component

GO:0005737	cytoplasm
GO:0005759	mitochondrial matrix
GO:0030529	ribonucleoprotein complex
GO:0033391	chromatoid body
GO:0035770	ribonucleoprotein granule
GO:0043186	P granule