InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dnajb6

Summary

InnateDB Protein

IDBP-144787.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dnajb6

Protein Name

DnaJ (Hsp40) homolog, subfamily B, member 6

Synonyms

mDj4; Mrj;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000008733

InnateDB Gene

IDBG-144785 (Dnajb6)

Protein Structure

UniProt Annotation

Function

Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins (By similarity). Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	37 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001671	ATPase activator activity
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0031072	heat shock protein binding
GO:0051082	unfolded protein binding
GO:0051087	chaperone binding

Biological Process

GO:0006457	protein folding
GO:0030036	actin cytoskeleton organization
GO:0030198	extracellular matrix organization
GO:0032781	positive regulation of ATPase activity
GO:0034504	protein localization to nucleus
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045109	intermediate filament organization
GO:0045892	negative regulation of transcription, DNA-templated
GO:0060710	chorio-allantoic fusion
GO:0060715	syncytiotrophoblast cell differentiation involved in labyrinthine layer development
GO:0060717	chorion development
GO:0090084	negative regulation of inclusion body assembly