Version 5.4
Mus musculus Gene: Dnajb6
Summary
InnateDB Gene IDBG-144785.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dnajb6
Gene Name DnaJ (Hsp40) homolog, subfamily B, member 6
Synonyms mDj4; Mrj
Species Mus musculus
Ensembl Gene ENSMUSG00000029131
Encoded Proteins
IDBP-144787
DnaJ (Hsp40) homolog, subfamily B, member 6
IDBP-144789
DnaJ (Hsp40) homolog, subfamily B, member 6
IDBP-250915
DnaJ (Hsp40) homolog, subfamily B, member 6
IDBP-537423
DnaJ (Hsp40) homolog, subfamily B, member 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105993:
This gene encodes a member of the DNAJ protein family. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. This family member may also play a role in polyglutamine aggregation in specific neurons. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
This gene encodes a member of the DNAJ protein family. DNAJ family members are characterized by a highly conserved amino acid stretch called the \'J-domain\' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. This family member may also play a role in polyglutamine aggregation in specific neurons. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:29735688-29786478
Strand Forward strand
Band B1
Transcripts
ENSMUST00000008733 ENSMUSP00000008733
ENSMUST00000012734 ENSMUSP00000012734
ENSMUST00000114839 ENSMUSP00000110488
ENSMUST00000127753
ENSMUST00000151976
ENSMUST00000149553
ENSMUST00000149396
ENSMUST00000140376 ENSMUSP00000117159
ENSMUST00000139126
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 37 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001671 ATPase activator activity
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0031072 heat shock protein binding
GO:0051082 unfolded protein binding
GO:0051087 chaperone binding
Biological Process
GO:0006457 protein folding
GO:0030036 actin cytoskeleton organization
GO:0030198 extracellular matrix organization
GO:0032781 positive regulation of ATPase activity
GO:0034504 protein localization to nucleus
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045109 intermediate filament organization
GO:0045892 negative regulation of transcription, DNA-templated
GO:0060710 chorio-allantoic fusion
GO:0060715 syncytiotrophoblast cell differentiation involved in labyrinthine layer development
GO:0060717 chorion development
GO:0090084 negative regulation of inclusion body assembly
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0030018 Z disc
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000105993
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt O54946
TrEMBL
UniProt Splice Variant
Entrez Gene 23950
UniGene Mm.290110 Mm.400027 Mm.483283
RefSeq NM_001127367 NM_011847 NM_001037940 NM_001037941
OMIM
CCDS CCDS39043 CCDS19151 CCDS19152
HPRD
IMGT
MGI ID MGI:1344381
MGI Symbol Dnajb6
EMBL AB028854 AF035962 AK133805 AK134387 AK144182 AK151219 AK151752 AK152626 AK152632 AK153091 AK169332 AK169767 BC003702 BC083349
GenPept AAC16759 AAH03702 AAH83349 BAA88302 BAE21853 BAE22124 BAE25752 BAE30213 BAE30661 BAE31369 BAE31375 BAE31714 BAE41085 BAE41354
RNA Seq Atlas 23950

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca