Version 5.4
Mus musculus Protein: Vps37c
Summary
InnateDB Protein IDBP-144870.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Vps37c
Protein Name vacuolar protein sorting 37C (yeast)
Synonyms 5730409F24Rik; AU042646;
Species Mus musculus
Ensembl Protein ENSMUSP00000085264
InnateDB Gene IDBG-144868 (Vps37c)
Protein Structure
UniProt Annotation
Function Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation (By similarity). {ECO:0000250}.
Subcellular Localization Late endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Probably associates with membranes. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0015031 protein transport
Cellular Component
GO:0000813 ESCRT I complex
GO:0005634 nucleus
GO:0031902 late endosome membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:2147661
InterPro IPR009851 Modifier of rudimentary, Modr
PFAM PF07200
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8R105
PhosphoSite PhosphoSite-Q8R105
TrEMBL
UniProt Splice Variant
Entrez Gene 107305
UniGene Mm.19091
RefSeq NP_852068
MGI ID
MGI Symbol Vps37c
OMIM
CCDS CCDS29585
HPRD
IMGT
EMBL AK158833 AK159309 BC025865
GenPept AAH25865 BAE34687 BAE34977

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca