InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UGDH

Summary

InnateDB Protein

IDBP-14495.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UGDH

Protein Name

UDP-glucose 6-dehydrogenase

Synonyms

GDH; UDP-GlcDH; UDPGDH; UGD;

Species

Homo sapiens

Ensembl Protein

ENSP00000319501

InnateDB Gene

IDBG-14491 (UGDH)

Protein Structure

UniProt Annotation

Function

Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.

Subcellular Localization

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:9850599}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.

Experimentally validated
Total	29 [view]
Protein-Protein	27 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003979	UDP-glucose 6-dehydrogenase activity
GO:0009055	electron carrier activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287	NAD binding

Biological Process

GO:0001702	gastrulation with mouth forming second
GO:0006011	UDP-glucose metabolic process
GO:0006024	glycosaminoglycan biosynthetic process
GO:0006065	UDP-glucuronate biosynthetic process
GO:0006805	xenobiotic metabolic process
GO:0044281	small molecule metabolic process
GO:0052695	cellular glucuronidation
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR001732 UDP-glucose/GDP-mannose dehydrogenase, N-terminal
IPR008927 6-phosphogluconate dehydrogenase, C-terminal-like
IPR014026 UDP-glucose/GDP-mannose dehydrogenase, dimerisation
IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal
IPR017476 UDP-glucose/GDP-mannose dehydrogenase

PFAM

PF03721
PF00984
PF03720

PRINTS

PIRSF

PIRSF000124

SMART

SM00984

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt