Version 5.4
Homo sapiens Gene: UGDH
Summary
InnateDB Gene IDBG-14491.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UGDH
Gene Name UDP-glucose 6-dehydrogenase
Synonyms GDH; UDP-GlcDH; UDPGDH; UGD
Species Homo sapiens
Ensembl Gene ENSG00000109814
Encoded Proteins
IDBP-14495
UDP-glucose 6-dehydrogenase
IDBP-481929
UDP-glucose 6-dehydrogenase
IDBP-478210
UDP-glucose 6-dehydrogenase
IDBP-485202
UDP-glucose 6-dehydrogenase
IDBP-475005
UDP-glucose 6-dehydrogenase
IDBP-475750
UDP-glucose 6-dehydrogenase
IDBP-474881
UDP-glucose 6-dehydrogenase
IDBP-484098
UDP-glucose 6-dehydrogenase
IDBP-473550
UDP-glucose 6-dehydrogenase
IDBP-477746
UDP-glucose 6-dehydrogenase
IDBP-476262
UDP-glucose 6-dehydrogenase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:39498755-39528311
Strand Reverse strand
Band p14
Transcripts
ENST00000316423 ENSP00000319501
ENST00000501493 ENSP00000422909
ENST00000506179 ENSP00000421757
ENST00000507089 ENSP00000426560
ENST00000515021 ENSP00000421954
ENST00000514106 ENSP00000425834
ENST00000510881 ENSP00000424059
ENST00000503779 ENSP00000424435
ENST00000509391 ENSP00000422603
ENST00000515398
ENST00000505698 ENSP00000422565
ENST00000510490 ENSP00000427708
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
Experimentally validated
Total 29 [view]
Protein-Protein 27 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003979 UDP-glucose 6-dehydrogenase activity
GO:0009055 electron carrier activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding
Biological Process
GO:0001702 gastrulation with mouth forming second
GO:0006011 UDP-glucose metabolic process
GO:0006024 glycosaminoglycan biosynthetic process
GO:0006065 UDP-glucuronate biosynthetic process
GO:0006805 xenobiotic metabolic process
GO:0044281 small molecule metabolic process
GO:0052695 cellular glucuronidation
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029201
View Gene Order
ENSBTAG00000014521
Not yet available
Pathways
NETPATH
REACTOME
REACT_6737
Formation of the active cofactor, UDP-glucuronate pathway
REACT_6784
Glucuronidation pathway
REACT_6959
Phase II conjugation pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
KEGG
hsa00520
Amino sugar and nucleotide sugar metabolism pathway
hsa00040
Pentose and glucuronate interconversions pathway
hsa00500
Starch and sucrose metabolism pathway
hsa00053
Ascorbate and aldarate metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.572518
RefSeq NM_001184700 NM_001184701 NM_003359 XM_005262667 XM_006714029
HUGO
OMIM
CCDS CCDS3455 CCDS54757 CCDS54758
HPRD 04535
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca