InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fnta

Summary

InnateDB Protein

IDBP-144957.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fnta

Protein Name

farnesyltransferase, CAAX box, alpha

Synonyms

FTA;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000016138

InnateDB Gene

IDBG-144955 (Fnta)

Protein Structure

UniProt Annotation

Function

Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation. {ECO:0000269PubMed:14622576, ECO:0000269PubMed:21520375}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004660	protein farnesyltransferase activity
GO:0004661	protein geranylgeranyltransferase activity
GO:0004662	CAAX-protein geranylgeranyltransferase activity
GO:0004663	Rab geranylgeranyltransferase activity
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0008318	protein prenyltransferase activity
GO:0030548	acetylcholine receptor regulator activity
GO:0030971	receptor tyrosine kinase binding
GO:0043014	alpha-tubulin binding

Biological Process

GO:0010469	regulation of receptor activity
GO:0018342	protein prenylation
GO:0018343	protein farnesylation
GO:0018344	protein geranylgeranylation
GO:0045213	neurotransmitter receptor metabolic process
GO:0090044	positive regulation of tubulin deacetylation
GO:0090045	positive regulation of deacetylase activity