InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Smad9

Summary

InnateDB Protein

IDBP-144969.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Smad9

Protein Name

MAD homolog 9 (Drosophila)

Synonyms

MADH6; Madh8; Madh9; Smad8;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029371

InnateDB Gene

IDBG-144967 (Smad9)

Protein Structure

UniProt Annotation

Function

Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD). Has been shown to be activated by activin type I receptor-like kinases (ALK-2, ALK-3, ALK-6) which stimulate heteromerization between SMAD9 and SMAD4. May play a role in osteoblast differentiation and maturation.

Subcellular Localization

Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 101 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	101 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0001657	ureteric bud development
GO:0001666	response to hypoxia
GO:0001880	Mullerian duct regression
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0030509	BMP signaling pathway
GO:0030901	midbrain development
GO:0030902	hindbrain development
GO:0045597	positive regulation of cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0051216	cartilage development
GO:0060348	bone development
GO:0071407	cellular response to organic cyclic compound

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1859993

InterPro

IPR001132 SMAD domain, Dwarfin-type
IPR003619 MAD homology 1, Dwarfin-type
IPR008984 SMAD/FHA domain
IPR013019 MAD homology, MH1
IPR019471 Interferon regulatory factor-3

PFAM

PF03166
PF03165
PF10401

PRINTS

PIRSF

SMART

SM00524
SM00523

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JIW5