InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trim36

Summary

InnateDB Protein

IDBP-145015.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trim36

Protein Name

tripartite motif-containing 36

Synonyms

D18Wsu100e; haprin;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000037978

InnateDB Gene

IDBG-145013 (Trim36)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation. May play a role in the acrosome reaction and fertilization. {ECO:0000269PubMed:12917430, ECO:0000269PubMed:19232519}.

Subcellular Localization

Cytoplasm. Cytoplasmic vesicle, secretory vesicle, acrosome. Cytoplasm, cytoskeleton. Note=Found in the acrosomal region of elongated spermatids and mature sperm.

Disease Associations

Tissue Specificity

Expressed only in testis. {ECO:0000269PubMed:12917430}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0007340	acrosome reaction
GO:0016567	protein ubiquitination
GO:0051726	regulation of cell cycle

Cellular Component

GO:0001669	acrosomal vesicle
GO:0005622	intracellular
GO:0005856	cytoskeleton
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:106264

InterPro

IPR000315 Zinc finger, B-box
IPR001841 Zinc finger, RING-type
IPR001870 B30.2/SPRY domain
IPR003877 SPla/RYanodine receptor SPRY
IPR003961 Fibronectin, type III
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR018957 Zinc finger, C3HC4 RING-type

PFAM