InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ly86

Summary

InnateDB Protein

IDBP-145272.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ly86

Protein Name

lymphocyte antigen 86

Synonyms

MD-1; MD1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021860

InnateDB Gene

IDBG-145270 (Ly86)

Protein Structure

UniProt Annotation

Function

May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression. {ECO:0000269PubMed:10925274}.

Subcellular Localization

Secreted, extracellular space. Note=Associated with CD180 at the cell surface.

Disease Associations

Tissue Specificity

Highly expressed in spleen, liver, brain and thymus, and at lower levels in kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	4 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0006954	inflammatory response
GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0045087	innate immune response (InnateDB)