InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sav1

Summary

InnateDB Protein

IDBP-145304.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sav1

Protein Name

salvador homolog 1 (Drosophila)

Synonyms

1700040G09Rik; Salv; Sav; WW45; Wwp3; Wwp4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021467

InnateDB Gene

IDBG-145302 (Sav1)

Protein Structure

UniProt Annotation

Function

Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed in adult tissues with the highest level found in testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001942	hair follicle development
GO:0007165	signal transduction
GO:0030216	keratinocyte differentiation
GO:0035329	hippo signaling
GO:0043065	positive regulation of apoptotic process
GO:0046620	regulation of organ growth
GO:0050680	negative regulation of epithelial cell proliferation
GO:0060044	negative regulation of cardiac muscle cell proliferation
GO:0060412	ventricular septum morphogenesis
GO:0060487	lung epithelial cell differentiation
GO:0060575	intestinal epithelial cell differentiation
GO:2000036	regulation of stem cell maintenance