Version 5.4
Mus musculus Protein: Atg12
Summary
InnateDB Protein IDBP-145434.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Atg12
Protein Name autophagy-related 12 (yeast)
Synonyms 4931423H11Rik; A330058M13Rik; Apg12l; Atg12l;
Species Mus musculus
Ensembl Protein ENSMUSP00000038489
InnateDB Gene IDBG-145432 (Atg12)
Protein Structure
UniProt Annotation
Function Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus. {ECO:0000269PubMed:11266458, ECO:0000269PubMed:12890687, ECO:0000269PubMed:20723759}.
Subcellular Localization Cytoplasm {ECO:0000250}. Preautophagosomal structure membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=TECPR1 recruits the ATG12-ATG5 conjugate to the autolysosomal membrane. {ECO:0000250}.
Disease Associations
Tissue Specificity Ubiquitous.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 65 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 16 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 65 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000045 autophagic vacuole assembly
GO:0006914 autophagy
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0034045 pre-autophagosomal structure membrane
GO:0043234 protein complex
Protein Structure and Domains
PDB ID MGI:1914776
InterPro IPR004241 Autophagy protein Atg8 ubiquitin like
IPR007242 Ubiquitin-like protein Atg12
IPR029071 Ubiquitin-related domain
PFAM PF02991
PF04110
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CQY1
PhosphoSite PhosphoSite-Q9CQY1
TrEMBL
UniProt Splice Variant
Entrez Gene 67526
UniGene Mm.9852
RefSeq NP_080493
MGI ID
MGI Symbol Atg12
OMIM
CCDS CCDS37811
HPRD
IMGT
EMBL AB066216 AK005405 AK008698 AK016474 AK167027 BC070470
GenPept AAH70470 BAB24005 BAB25839 BAB30256 BAB62092 BAE39200

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca