InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: APC2

Summary

InnateDB Protein

IDBP-14551.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APC2

Protein Name

adenomatosis polyposis coli 2

Synonyms

APCL;

Species

Homo sapiens

Ensembl Protein

ENSP00000233607

InnateDB Gene

IDBG-14549 (APC2)

Protein Structure

UniProt Annotation

Function

Promotes rapid degradation of CTNNB1 and may function as a tumor suppressor. May function in Wnt signaling. {ECO:0000269PubMed:10021369, ECO:0000269PubMed:11691822, ECO:0000269PubMed:9823329}.

Subcellular Localization

Cytoplasm, cytoskeleton. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated with actin filaments and the microtubule network.

Disease Associations

Tissue Specificity

Widely expressed (at protein level). Specifically expressed in the CNS. {ECO:0000269PubMed:10021369, ECO:0000269PubMed:11691822, ECO:0000269PubMed:9823329}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	28 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008017	microtubule binding

Biological Process

GO:0016055	Wnt signaling pathway
GO:0030178	negative regulation of Wnt signaling pathway
GO:0035414	negative regulation of catenin import into nucleus
GO:0090090	negative regulation of canonical Wnt signaling pathway

Cellular Component

GO:0000139	Golgi membrane
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005881	cytoplasmic microtubule
GO:0005884	actin filament
GO:0015630	microtubule cytoskeleton
GO:0016342	catenin complex
GO:0031258	lamellipodium membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000225 Armadillo
IPR009053 Prefoldin
IPR009223 Adenomatous polyposis coli protein, cysteine-rich repeat
IPR009224 SAMP
IPR009234 Adenomatous polyposis coli protein basic domain
IPR016024 Armadillo-type fold
IPR026831 Adenomatous polyposis coli domain

PFAM

PF00514
PF05923
PF05924
PF05956
PF11414

PRINTS

PIRSF

SMART

SM00185

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O95996