Homo sapiens Gene: APC2
Summary
InnateDB Gene IDBG-14549.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APC2
Gene Name adenomatosis polyposis coli 2
Synonyms APCL;
Species Homo sapiens
Ensembl Gene ENSG00000115266
Encoded Proteins
adenomatosis polyposis coli 2
adenomatosis polyposis coli 2
adenomatosis polyposis coli 2
Protein Structure
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 19:1446302-1473244
Strand Forward strand
Band p13.3
Transcripts
ENST00000233607 ENSP00000233607
ENST00000238483 ENSP00000238483
ENST00000535453 ENSP00000442954
ENST00000593146
ENST00000590877 ENSP00000466173
ENST00000587869 ENSP00000466803
ENST00000590469 ENSP00000467073
ENST00000587149 ENSP00000468199
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 28 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0008017 microtubule binding
Biological Process
GO:0016055 Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0035414 negative regulation of catenin import into nucleus
GO:0090090 negative regulation of canonical Wnt signaling pathway
Cellular Component
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005881 cytoplasmic microtubule
GO:0005884 actin filament
GO:0015630 microtubule cytoskeleton
GO:0016342 catenin complex
GO:0031258 lamellipodium membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Wnt signaling pathway pathway
Regulation of actin cytoskeleton pathway
Pathways in cancer pathway
Colorectal cancer pathway
Endometrial cancer pathway
Basal cell carcinoma pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O95996
TrEMBL K7ELQ3 K7EN62
UniProt Splice Variant
Entrez Gene 10297
UniGene Hs.446376
RefSeq NM_005883 XM_005259475 XM_006722607 XM_006722608 XM_006722609 XM_006722610
HUGO HGNC:24036
OMIM 612034
CCDS CCDS12068
HPRD 09802
IMGT
EMBL AB012162 AB022529 AC027307 AF110334 AF110335 AF110336 AF110337 AF128222 AJ012652 AJ131187 BC032573 CH471139
GenPept AAD28183 AAD29273 AAD29274 AAF01784 AAH32573 BAA34611 BAA75469 CAA10317 CAB61207 EAW69498
ImmGen APC2 (murine)
RNA Seq Atlas 10297