Homo sapiens Gene: APC2

Summary
InnateDB Gene IDBG-14549.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol APC2
Gene Name adenomatosis polyposis coli 2
Synonyms APCL
Species Homo sapiens
Ensembl Gene ENSG00000115266
Encoded Proteins
IDBP-14551 adenomatosis polyposis coli 2
IDBP-14553 adenomatosis polyposis coli 2
IDBP-592979 adenomatosis polyposis coli 2
IDBP-765913
IDBP-763654
IDBP-766082
IDBP-762019
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 19: 1446300-1473243
Strand Forward strand
Band p13.3
Transcripts
ENST00000233607  ENSP00000233607
ENST00000238483  ENSP00000238483
ENST00000535453  ENSP00000442954
ENST00000593146 
ENST00000590877  ENSP00000466173
ENST00000587869  ENSP00000466803
ENST00000590469  ENSP00000467073
ENST00000587149  ENSP00000468199
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein‑Protein  23
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Predicted by orthology
Total [view]
Gene Ontology
Accession GO Term
Molecular Function
GO:0005488 binding
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0008017 microtubule binding
Biological Process
GO:0016055 Wnt receptor signaling pathway
GO:0035414 negative regulation of catenin import into nucleus
GO:0090090 negative regulation of canonical Wnt receptor signaling pathway
Cellular Component
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005881 cytoplasmic microtubule
GO:0005884 actin filament
GO:0016342 catenin complex
GO:0031258 lamellipodium membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000020135 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000015433 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
hsa05217  Basal cell carcinoma
hsa05210  Colorectal cancer
hsa05213  Endometrial cancer
hsa05200  Pathways in cancer
hsa04810  Regulation of actin cytoskeleton
hsa04310  Wnt signaling pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O95996 
TrEMBL B5MDS5
UniProt Splice Variant
Entrez Gene 10297 
UniGene Hs.446376
RefSeq NM_005883 
HUGO 24036 
OMIM 612034
CCDS CCDS12068 
HPRD 09802
IMGT
EMBL AB012162 AB022529 AC027307 AF110334 AF110335 AF110336 AF110337 AF128222 AJ012652 AJ131187 BC032573 CH471139
GenPept AAD28183  AAD29273  AAD29274  AAF01784  AAH32573  BAA34611  BAA75469  CAA10317  CAB61207  EAW69498 
ImmGen APC2 (murine) 
RNA Seq Atlas 10297