InnateDB Protein
|
IDBP-145516.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Crx
|
Protein Name
|
cone-rod homeobox containing gene
|
Synonyms
|
Crx1;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000043436
|
InnateDB Gene
|
IDBG-145514 (Crx)
|
Protein Structure
|
|
Function |
Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors. {ECO:0000269PubMed:16574740}.
|
Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00108, ECO:0000269PubMed:16574740}.
|
Disease Associations |
|
Tissue Specificity |
Retina. {ECO:0000269PubMed:16574740}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
|
Protein-Protein |
2
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:1194883
|
InterPro |
IPR001356
Homeobox domain
IPR009057
Homeodomain-like
IPR013851
Transcription factor Otx, C-terminal
|
PFAM |
PF00046
PF03529
|
PRINTS |
|
PIRSF |
|
SMART |
SM00389
|
TIGRFAMs |
|
Modification |
|
SwissProt |
O54751
|
PhosphoSite |
PhosphoSite-
|
TrEMBL |
Q543C9
|
UniProt Splice Variant |
|
Entrez Gene |
12951
|
UniGene |
Mm.441911
|
RefSeq |
NP_031796
|
MGI ID |
|
MGI Symbol |
Crx
|
OMIM |
|
CCDS |
CCDS20840
|
HPRD |
|
IMGT |
|
EMBL |
AC148990
AK053533
AK139691
BC016502
CH466654
U77615
|
GenPept |
AAB88585
AAH16502
BAC35418
BAE24107
EDL42122
|
|
|