Version 5.4
| Mus musculus Protein: Sepw1 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-145593.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Sepw1 | ||||||||
| Protein Name | selenoprotein W, muscle 1 | ||||||||
| Synonyms | selW; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000038943 | ||||||||
| InnateDB Gene | IDBG-145591 (Sepw1) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency. {ECO:0000269PubMed:12062442, ECO:0000269PubMed:16876868, ECO:0000269PubMed:17503775}. | ||||||||
| Subcellular Localization | Cytoplasm. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | In the embryo, expressed in the developing nervous system and in mesoderm-derived tissues such as heart and limbs. In the adult, predominantly expressed in brain, skeletal muscle and heart. {ECO:0000269PubMed:16876868, ECO:0000269PubMed:17503775}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:1100878 | ||||||||
| InterPro |
IPR011893
Selenoprotein, Rdx type IPR012336 Thioredoxin-like fold |
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| PFAM |
PF10262
PF13098 PF13192 PF13462 PF13905 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART | |||||||||
| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | P63300 | ||||||||
| PhosphoSite | PhosphoSite- | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 20364 | ||||||||
| UniGene | |||||||||
| RefSeq | NP_033182 | ||||||||
| MGI ID | 2NPB | ||||||||
| MGI Symbol | Sepw1 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS39778 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AF015284 AF241527 AK002870 AK028124 BC052719 U67890 | ||||||||
| GenPept | AAB69860 AAC53317 AAF64481 AAH52719 BAC55247 BAC55256 | ||||||||