Mus musculus Protein: Gpr44 | |||||||||||
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Summary | |||||||||||
InnateDB Protein | IDBP-145610.7 | ||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
Gene Symbol | Gpr44 | ||||||||||
Protein Name | G protein-coupled receptor 44 | ||||||||||
Synonyms | Crth2; Gpr44; Grp45; | ||||||||||
Species | Mus musculus | ||||||||||
Ensembl Protein | ENSMUSP00000036159 | ||||||||||
InnateDB Gene | IDBG-145608 (Gpr44) | ||||||||||
Protein Structure | |||||||||||
UniProt Annotation | |||||||||||
Function | Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin- sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses (By similarity). {ECO:0000250}. | ||||||||||
Subcellular Localization | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Internalized receptors colocalized with RAB11A. {ECO:0000250}. | ||||||||||
Disease Associations | |||||||||||
Tissue Specificity | |||||||||||
Comments | |||||||||||
Interactions | |||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||
PDB ID | MGI:1330275 | ||||||||||
InterPro |
IPR000276
G protein-coupled receptor, rhodopsin-like IPR002234 Anaphylatoxin chemotactic receptor family IPR017452 GPCR, rhodopsin-like, 7TM |
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PFAM |
PF00001
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PRINTS |
PR00237
PR01104 |
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PIRSF | |||||||||||
SMART | |||||||||||
TIGRFAMs | |||||||||||
Post-translational Modifications | |||||||||||
Modification | |||||||||||
Cross-References | |||||||||||
SwissProt | Q9Z2J6 | ||||||||||
PhosphoSite | PhosphoSite-Q9Z2J6 | ||||||||||
TrEMBL | |||||||||||
UniProt Splice Variant | |||||||||||
Entrez Gene | 14764 | ||||||||||
UniGene | Mm.470721 | ||||||||||
RefSeq | NP_034092 | ||||||||||
MGI ID | |||||||||||
MGI Symbol | Ptgdr2 | ||||||||||
OMIM | |||||||||||
CCDS | CCDS29592 | ||||||||||
HPRD | |||||||||||
IMGT | |||||||||||
EMBL | AB109091 AB109092 AF054507 BC111906 CH466534 | ||||||||||
GenPept | AAD13525 AAI11907 BAC81436 BAC81437 EDL41395 | ||||||||||