InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cnga3

Summary

InnateDB Protein

IDBP-145669.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cnga3

Protein Name

cyclic nucleotide gated channel alpha 3

Synonyms

CNG3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027288

InnateDB Gene

IDBG-145667 (Cnga3)

Protein Structure

UniProt Annotation

Function

Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones (By similarity). Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3. {ECO:0000250, ECO:0000269PubMed:10662822}.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Prominently expressed in retina.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005221	intracellular cyclic nucleotide activated cation channel activity
GO:0005222	intracellular cAMP activated cation channel activity
GO:0005223	intracellular cGMP activated cation channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0030553	cGMP binding

Biological Process

GO:0006811	ion transport
GO:0006812	cation transport
GO:0007601	visual perception
GO:0007603	phototransduction, visible light
GO:0031960	response to corticosteroid
GO:0032026	response to magnesium ion
GO:0034220	ion transmembrane transport
GO:0042391	regulation of membrane potential
GO:0046549	retinal cone cell development
GO:0051591	response to cAMP
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0001750	photoreceptor outer segment
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0030425	dendrite
GO:0042622	photoreceptor outer segment membrane
GO:0043025	neuronal cell body
GO:0043204	perikaryon
GO:1902495	transmembrane transporter complex