InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Jam3

Summary

InnateDB Protein

IDBP-145912.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Jam3

Protein Name

junction adhesion molecule 3

Synonyms

1110002N23Rik; JAM-3; JAM-C; Jcam3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034472

InnateDB Gene

IDBG-145910 (Jam3)

Protein Structure

UniProt Annotation

Function

Participates in cell-cell adhesion. It is a counter- receptor for ITGAM mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN) (By similarity). The soluble form is a mediator of angiogenesis. {ECO:0000250, ECO:0000269PubMed:11739175, ECO:0000269PubMed:15994945, ECO:0000269PubMed:20592283}.

Subcellular Localization

Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell junction, desmosome {ECO:0000250}. Secreted, extracellular space {ECO:0000250}. Note=In epithelial cells, it is expressed at desmosomes but not at tight junctions. Localizes at the cell surface of endothelial cells. Treatment of endothelial cells with vascular endothelial growth factor stimulates recruitment of JAM3 to cell-cell contacts (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Endothelial cells. {ECO:0000269PubMed:11739175}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001525	angiogenesis
GO:0001780	neutrophil homeostasis
GO:0002250	adaptive immune response
GO:0002318	myeloid progenitor cell differentiation
GO:0002523	leukocyte migration involved in inflammatory response
GO:0007155	cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007283	spermatogenesis
GO:0007286	spermatid development
GO:0016477	cell migration
GO:0019226	transmission of nerve impulse
GO:0030010	establishment of cell polarity
GO:0031103	axon regeneration
GO:0042552	myelination
GO:0045087	innate immune response (InnateDB)
GO:0090022	regulation of neutrophil chemotaxis
GO:0090138	regulation of actin cytoskeleton organization by cell-cell adhesion

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005923	tight junction
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0030057	desmosome
GO:0033010	paranodal junction
GO:0043220	Schmidt-Lanterman incisure
GO:0044291	cell-cell contact zone

Protein Structure and Domains

PDB ID

MGI:1933825

InterPro

IPR003596 Immunoglobulin V-set, subgroup
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
IPR013162 CD80-like, immunoglobulin C2-set

PFAM

PF07679
PF07686
PF00047
PF08205

PRINTS

PIRSF

SMART

SM00406
SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9D8B7