InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Jam3

Summary

InnateDB Gene

IDBG-145910.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Jam3

Gene Name

junction adhesion molecule 3

Synonyms

1110002N23Rik; JAM-3; JAM-C; Jcam3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031990

Encoded Proteins

IDBP-145912

junction adhesion molecule 3

IDBP-622371

junction adhesion molecule 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21706006

Jam3 is a key regulator of polarized neutrophil transendothelial migration in vivo.

InnateDB Annotation from Orthologs

Summary

PMID 21706006

[Homo sapiens] JAM3 is a key regulator of polarized neutrophil transendothelial migration in vivo. (Demonstrated in murine model)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166086:
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. A mutation in an intron of this gene is associated with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:27097385-27155421

Strand

Reverse strand

Band

Transcripts

ENSMUST00000034472	ENSMUSP00000034472
ENSMUST00000167074	ENSMUSP00000128003

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001525	angiogenesis
GO:0001780	neutrophil homeostasis
GO:0002250	adaptive immune response
GO:0002318	myeloid progenitor cell differentiation
GO:0002523	leukocyte migration involved in inflammatory response
GO:0007155	cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007283	spermatogenesis
GO:0007286	spermatid development
GO:0016477	cell migration
GO:0019226	transmission of nerve impulse
GO:0030010	establishment of cell polarity
GO:0031103	axon regeneration
GO:0042552	myelination
GO:0045087	innate immune response (InnateDB)
GO:0090022	regulation of neutrophil chemotaxis
GO:0090138	regulation of actin cytoskeleton organization by cell-cell adhesion

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005923	tight junction
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0030057	desmosome
GO:0033010	paranodal junction
GO:0043220	Schmidt-Lanterman incisure
GO:0044291	cell-cell contact zone