InnateDB Protein
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IDBP-145949.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Eif4ebp1
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Protein Name
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eukaryotic translation initiation factor 4E binding protein 1
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Synonyms
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4e-bp1; AA959816; PHAS-I;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000033880
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InnateDB Gene
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IDBG-145947 (Eif4ebp1)
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Protein Structure
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Function |
Regulates eIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. {ECO:0000269PubMed:7629182}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
Highest expression in fat cells. {ECO:0000269PubMed:7629182}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Experimentally validated |
Total |
12
[view]
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Protein-Protein |
11
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
24 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:103267
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InterPro |
IPR008606
Eukaryotic translation initiation factor 4E binding
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PFAM |
PF05456
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q60876
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PhosphoSite |
PhosphoSite-Q60876
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
13685
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UniGene |
Mm.6700
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RefSeq |
NP_031944
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MGI ID |
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MGI Symbol |
Eif4ebp1
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OMIM |
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CCDS |
CCDS22214
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HPRD |
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IMGT |
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EMBL |
AK013033
AK169979
AK170031
BC002045
U28656
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GenPept |
AAA88818
AAH02045
BAB28612
BAE41494
BAE41521
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