Version 5.4
Mus musculus Protein: Gpnmb
Summary
InnateDB Protein IDBP-146082.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gpnmb
Protein Name glycoprotein (transmembrane) nmb
Synonyms DC-HIL; Dchil; ipd;
Species Mus musculus
Ensembl Protein ENSMUSP00000031840
InnateDB Gene IDBG-146080 (Gpnmb)
Protein Structure
UniProt Annotation
Function Could be a melanogenic enzyme. {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Endomembrane system {ECO:0000269PubMed:12638126}; Single-pass type I membrane protein {ECO:0000269PubMed:12638126}. Cytoplasmic vesicle membrane {ECO:0000269PubMed:12638126}; Single-pass type I membrane protein {ECO:0000269PubMed:12638126}. Melanosome {ECO:0000250}. Note=Vesicular, endosomal like structures.
Disease Associations Note=May promote bone metastatic phenotype when overexpressed in breast cancer cells. {ECO:0000269PubMed:17951401}.
Tissue Specificity In early development, mRNA is detected at high levels in the outer layer of the retina. Later in development expression gets restricted to the retinal pigment epithelium and iris. Overexpressed in mammary cancer cells possessing a strong bone metastatic phenotype. {ECO:0000269PubMed:12638126}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005178 integrin binding
GO:0008201 heparin binding
Biological Process
GO:0001649 osteoblast differentiation
GO:0007155 cell adhesion
GO:0030282 bone mineralization
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0012505 endomembrane system
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030659 cytoplasmic vesicle membrane
GO:0042470 melanosome
Protein Structure and Domains
PDB ID MGI:1934765
InterPro IPR000601 PKD domain
IPR022409 PKD/Chitinase domain
PFAM PF00801
PRINTS
PIRSF
SMART SM00089
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99P91
PhosphoSite PhosphoSite-Q99P91
TrEMBL Q3UE75
UniProt Splice Variant
Entrez Gene 93695
UniGene Mm.302602
RefSeq NP_444340
MGI ID
MGI Symbol Gpnmb
OMIM
CCDS CCDS20122
HPRD
IMGT
EMBL AF322054 AJ251685 AK044764 AK076347 AK149700 AK150739 AK154617 AK170506 AK171441 AK171465 AK171474 AK171517 BC026375
GenPept AAH26375 AAK14240 BAC32074 BAC36306 BAE29036 BAE29813 BAE32716 BAE41844 BAE42454 BAE42471 BAE42479 BAE42501 CAB65272

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca