InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Alg2

Summary

InnateDB Protein

IDBP-146147.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Alg2

Protein Name

asparagine-linked glycosylation 2 homolog (yeast, alpha-1,3-mannosyltransferase)

Synonyms

1110018A23Rik; 1300013N08Rik; ALPG2; CDGIi; MNCb-5081;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000043580

InnateDB Gene

IDBG-146145 (Alg2)

Protein Structure

UniProt Annotation

Function

Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)- dolichol diphosphate. {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000033	alpha-1,3-mannosyltransferase activity
GO:0004378	GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity
GO:0005515	protein binding
GO:0033164	glycolipid 6-alpha-mannosyltransferase activity
GO:0043495	protein anchor
GO:0046982	protein heterodimerization activity
GO:0047485	protein N-terminus binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0006488	dolichol-linked oligosaccharide biosynthetic process
GO:0009058	biosynthetic process
GO:0033577	protein glycosylation in endoplasmic reticulum
GO:0051592	response to calcium ion
GO:0097502	mannosylation