InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pfn2

Summary

InnateDB Protein

IDBP-146221.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pfn2

Protein Name

profilin 2

Synonyms

Pfn;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000068890

InnateDB Gene

IDBG-146219 (Pfn2)

Protein Structure

UniProt Annotation

Function

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.

Subcellular Localization

Cytoplasm, cytoskeleton.

Disease Associations

Tissue Specificity

Isoform IIa is the main isoform and is abundant in brain. Isoform IIb is a minor isoform.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000774	adenyl-nucleotide exchange factor activity
GO:0003779	actin binding
GO:0003785	actin monomer binding
GO:0005515	protein binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding

Biological Process

GO:0010633	negative regulation of epithelial cell migration
GO:0030036	actin cytoskeleton organization
GO:0030837	negative regulation of actin filament polymerization
GO:0030838	positive regulation of actin filament polymerization
GO:0032233	positive regulation of actin filament bundle assembly
GO:0032781	positive regulation of ATPase activity
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0051496	positive regulation of stress fiber assembly
GO:1900028	negative regulation of ruffle assembly
GO:2000300	regulation of synaptic vesicle exocytosis