InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hsd17b4

Summary

InnateDB Protein

IDBP-146227.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hsd17b4

Protein Name

hydroxysteroid (17-beta) dehydrogenase 4

Synonyms

17-beta-HSD; 17[b]-HSD; 4; DBP; MFE-2; Mfp-2; MFP2; MPF-2; perMFE-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025385

InnateDB Gene

IDBG-146225 (Hsd17b4)

Protein Structure

UniProt Annotation

Function

Bifunctional enzyme acting on the peroxisomal beta- oxidation pathway for fatty acids. Catalyzes the formation of 3- ketoacyl-CoA intermediates from both straight-chain and 2-methyl- branched-chain fatty acids (By similarity). {ECO:0000250}.

Subcellular Localization

Peroxisome {ECO:0000250}.

Disease Associations

Tissue Specificity

Present in many tissues with highest concentrations in liver and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	16 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity
GO:0005102	receptor binding
GO:0016491	oxidoreductase activity
GO:0016508	long-chain-enoyl-CoA hydratase activity
GO:0016853	isomerase activity
GO:0033989	3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity
GO:0042803	protein homodimerization activity
GO:0044594	17-beta-hydroxysteroid dehydrogenase (NAD+) activity

Biological Process

GO:0000038	very long-chain fatty acid metabolic process
GO:0001649	osteoblast differentiation
GO:0006635	fatty acid beta-oxidation
GO:0008152	metabolic process
GO:0008209	androgen metabolic process
GO:0008210	estrogen metabolic process
GO:0036111	very long-chain fatty-acyl-CoA metabolic process
GO:0036112	medium-chain fatty-acyl-CoA metabolic process
GO:0060009	Sertoli cell development

Cellular Component

GO:0005739	mitochondrion
GO:0005777	peroxisome
GO:0005778	peroxisomal membrane
GO:0016020	membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

MGI:105089

InterPro

IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
IPR002539 MaoC-like domain
IPR003033 SCP2 sterol-binding domain
IPR003560 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
IPR013968 Polyketide synthase, KR
IPR020842 Polyketide synthase/Fatty acid synthase, KR
IPR029069 HotDog domain

PFAM

PF00106
PF01575
PF02036
PF08659

PRINTS

PR00080
PR00081
PR01397

PIRSF

PIRSF000126

SMART

SM00822

TIGRFAMs

Post-translational Modifications

Modification

Cross-References