InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hsd17b4

Summary

InnateDB Gene

IDBG-146225.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hsd17b4

Gene Name

hydroxysteroid (17-beta) dehydrogenase 4

Synonyms

17-beta-HSD; 17[b]-HSD; 4; DBP; MFE-2; Mfp-2; MFP2; MPF-2; perMFE-2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024507

Encoded Proteins

IDBP-146227

hydroxysteroid (17-beta) dehydrogenase 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000133835:
The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:50128201-50196269

Strand

Forward strand

Band

Transcripts

ENSMUST00000025385	ENSMUSP00000025385
ENSMUST00000152388
ENSMUST00000139502
ENSMUST00000127325

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	16 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity
GO:0005102	receptor binding
GO:0016491	oxidoreductase activity
GO:0016508	long-chain-enoyl-CoA hydratase activity
GO:0016853	isomerase activity
GO:0033989	3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity
GO:0042803	protein homodimerization activity
GO:0044594	17-beta-hydroxysteroid dehydrogenase (NAD+) activity

Biological Process

GO:0000038	very long-chain fatty acid metabolic process
GO:0001649	osteoblast differentiation
GO:0006635	fatty acid beta-oxidation
GO:0008152	metabolic process
GO:0008209	androgen metabolic process
GO:0008210	estrogen metabolic process
GO:0036111	very long-chain fatty-acyl-CoA metabolic process
GO:0036112	medium-chain fatty-acyl-CoA metabolic process
GO:0060009	Sertoli cell development