Version 5.4
Mus musculus Protein: Bbc3
Summary
InnateDB Protein IDBP-146382.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Bbc3
Protein Name BCL2 binding component 3
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000002152
InnateDB Gene IDBG-146380 (Bbc3)
Protein Structure
UniProt Annotation
Function Essential mediator of p53/TP53-dependent and p53/TP53- independent apoptosis. Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53 (By similarity). Regulates ER stress-induced neuronal apoptosis. {ECO:0000250, ECO:0000269PubMed:21159964, ECO:0000269PubMed:22761832}.
Subcellular Localization Mitochondrion. Note=Localized to the mitochondria in order to induce cytochrome c release. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 3 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001836 release of cytochrome c from mitochondria
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0008340 determination of adult lifespan
GO:0030308 negative regulation of cell growth
GO:0034976 response to endoplasmic reticulum stress
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043065 positive regulation of apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0045926 negative regulation of growth
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070245 positive regulation of thymocyte apoptotic process
GO:0071479 cellular response to ionizing radiation
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
GO:0097190 apoptotic signaling pathway
GO:0097194 execution phase of apoptosis
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:2001056 positive regulation of cysteine-type endopeptidase activity
Cellular Component
GO:0005739 mitochondrion
GO:0005740 mitochondrial envelope
Protein Structure and Domains
PDB ID MGI:2181667
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99ML1
PhosphoSite PhosphoSite-Q99ML1
TrEMBL D3Z2M5
UniProt Splice Variant
Entrez Gene 170770
UniGene Mm.7660
RefSeq NP_573497
MGI ID 2VOF
MGI Symbol Bbc3
OMIM
CCDS CCDS20847
HPRD
IMGT
EMBL AC156630 AF332560 BC044782 BC060370 BC147261 BC147262 CH466654
GenPept AAH44782 AAH60370 AAI47262 AAI47263 AAK31317 EDL42101

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca